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This is why 65% of diabetics die from heart disease.

CD36 expression is also elevated in response exercise training and the 88 kDa protein translocates rapidly to the plasma membrane during muscle contraction.

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Regular insulin should look as clear as water.

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In elderly patients with diabetes, the initial dosing, dose increments, and maintenance dosage should be conservative to avoid hypoglycemic reactions.

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The introduction of better tools for the monitoring of glycemic control, coupled with evidence that near-normal glycosylated hemoglobin levels reduce the risk of diabetic complications, has increased the demand for insulin preparations that have greater effectiveness, safety, and versatility.

Several randomized controlled trials demonstrate less weight gain and hypoglycemia with the addition of metformin to insulin therapy.

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Insulin resistance is defined where a normal or elevated insulin level produces an attenuated biological response; classically this refers to impaired sensitivity to insulin mediated glucose disposal.

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Leptin and insulin appear to share a common signalling pathway in the hypothalamus.

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The αCT segment displaces the B-chain C-terminal β-strand away from the hormone core, revealing the mechanism of a long-proposed conformational switch in insulin upon receptor engagement.

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Overall, future trials are needed to (i) establish the effects of long-term training programs on prevention and reversal of MS; (ii) compare long-term effects of exercise versus drug therapy sustainability, as well as the potential synergistic or antagonizing effects of common drug therapies (statins, metformin, etc.

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