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Even though merely increasing your urine volume and fiddling with your electrolyte levels may sound benign, when taken improperly, diuretics can cause dehydration and potentially lethal electrolyte imbalance mess with your body salts.
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Although ranolazine is more expensive than other traditional treatments per dose, it actually cuts the non-pharmacy costs of care in the long run.
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Lopaschuk is an AHFMR Medical Scientist and was supported by grants from the Heart and Stroke Foundation of Alberta, the Canadian Diabetes Association, and the CIHR.
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AHA, etc) also recommends using ranolazine in circumstances in which other anti-anginal drugs are not adequately effective or are not tolerated.
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Patients may have modifiable risk factors that will put them at increased risk for continued medical problems related to CAD (see also “Preventable Risk Factors” earlier in this course).
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While some of these patients will go on to develop actual diastolic heart failure, many will not especially if they get appropriate medical care and take care of themselves.
They are contraindicated in patients who have severe aortic stenosis or hypertrophic cardiomyopathy because they can adversely alter hemodynamics and exacerbate symptoms.
Baseline and follow-up ECGs should be obtained to evaluate effects on QT interval.
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