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This is why 65% of diabetics die from heart disease.
CD36 expression is also elevated in response exercise training and the 88 kDa protein translocates rapidly to the plasma membrane during muscle contraction.
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Several randomized controlled trials demonstrate less weight gain and hypoglycemia with the addition of metformin to insulin therapy.
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Insulin resistance is defined where a normal or elevated insulin level produces an attenuated biological response; classically this refers to impaired sensitivity to insulin mediated glucose disposal.
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The αCT segment displaces the B-chain C-terminal β-strand away from the hormone core, revealing the mechanism of a long-proposed conformational switch in insulin upon receptor engagement.
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Overall, future trials are needed to (i) establish the effects of long-term training programs on prevention and reversal of MS; (ii) compare long-term effects of exercise versus drug therapy sustainability, as well as the potential synergistic or antagonizing effects of common drug therapies (statins, metformin, etc.
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